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The damage done to the kidneys amongst long-term steroid users has been noted as being more severe than kidney damage amongst morbidly obese people.
This could give some weight to the idea that the use of steroids may be linked with kidney problems. There is little doubt that the kidneys have a special function which needs to be properly maintained, and their damage may be a consequence of an imbalance of the normal balance of hormones. This also relates to the fact that steroid users are sometimes under-medicated with medicines that would normally be prescribed to non-users.
The research also found strong associations with the effects of the corticosteroids used, in particular infliximab and prednisone, which appear to be particularly harmful to the kidneys as they are known to inhibit one of the ways in which hormones are regulated in humans, the CYP450 enzymes.
The researchers hope their findings will encourage public health efforts to provide treatment for steroid users, including those over the age of 60, using drugs to control bone and joint pain such as glucocorticoids.
Explore further: Study links steroid use with prostate cancer among men over 65
More information: 'Disease Modification by Proteins and Antinociceptive Drugs Used in Steroid Administration', by Richard E Hynes, Christopher K Ghezman et al. Journal of Clinical Biochemistry (2016).
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